Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Urinary tract infections and reduced risk of bladder cancer in Los Angeles.

Authors: Jiang, X; Castelao, J E; Groshen, S; Cortessis, V K; Shibata, D; Conti, D V; Yuan, J-M; Pike, M C; Gago-Dominguez, M

Published In Br J Cancer, (2009 Mar 10)

Abstract: We investigated the association between urinary tract infections (UTIs) and transitional cell carcinoma of the bladder in a population-based case-control study in Los Angeles covering 1586 cases and age-, gender-, and race-matched neighbourhood controls. A history of bladder infection was associated with a reduced risk of bladder cancer among women (odds ratio (OR), 0.66; 95% confidence interval (CI), 0.46-0.96). No effect was found in men, perhaps due to power limitations. A greater reduction in bladder cancer risk was observed among women with multiple infections (OR, 0.37; 95% CI, 0.18-0.78). Exclusion of subjects with a history of diabetes, kidney or bladder stones did not change the inverse association. A history of kidney infections was not associated with bladder cancer risk, but there was a weak association between a history of other UTIs and slightly increased risk among men. Our results suggest that a history of bladder infection is associated with a reduced risk of bladder cancer among women. Cytotoxicity from antibiotics commonly used to treat bladder infections is proposed as one possible explanation.

PubMed ID: 19174821 Exiting the NIEHS site

MeSH Terms: Adult; Carcinoma, Transitional Cell/epidemiology*; Carcinoma, Transitional Cell/etiology*; Carcinoma, Transitional Cell/pathology; Case-Control Studies; Down-Regulation; Female; Humans; Los Angeles/epidemiology; Male; Middle Aged; Risk Factors; Sex Characteristics; Smoking/epidemiology; Urinary Bladder Neoplasms/epidemiology*; Urinary Bladder Neoplasms/etiology*; Urinary Bladder Neoplasms/pathology; Urinary Tract Infections/epidemiology*

Back
to Top