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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities.

Authors: Kasagami, Takeo; Kim, In-Hae; Tsai, Hsing-Ju; Nishi, Kosuke; Hammock, Bruce D; Morisseau, Christophe

Published In Bioorg Med Chem Lett, (2009 Mar 15)

Abstract: We investigated N-adamantyl-N'-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.

PubMed ID: 19216074 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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