Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Reliability of serum assays of iron status in postmenopausal women.

Authors: Zeleniuch-Jacquotte, Anne; Zhang, Qi; Dai, Jisen; Shore, Roy E; Arslan, Alan A; Koenig, Karen L; Karkoszka, Jerzy; Afanasyeva, Yelena; Frenkel, Krystyna; Toniolo, Paolo; Huang, Xi

Published In Ann Epidemiol, (2007 May)

Abstract: The aim of the study is to determine the reliability during a 2-year period of several newly developed iron-related assays to assess their potential for use in prospective epidemiologic studies.We assessed the temporal reliability of several iron-related assays by using three serum samples collected at yearly intervals from 50 postmenopausal participants in a large prospective study.We observed high reliability coefficients for ferritin (0.78; 95% confidence interval [CI], 0.67-0.86), soluble transferrin receptor (sTfR; 0.79; 95% CI, 0.69-0.87), sTfR/ferritin ratio (0.74; 95% CI, 0.62-0.83), and hepcidin (0.89; 95% CI, 0.84-0.94). In a subset of 30 women, lower reliability was observed for serum iron (0.50; 95% CI, 0.29-0.70), unsaturated iron-binding capacity (0.55; 95% CI, 0.34-0.73), total iron-binding capacity (0.60; 95% CI, 0.40-0.76), and serum transferrin saturation rate (0.44; 95% CI, 0.22-0.65). The reliability of anti-5-hydroxymethyl-2'-deoxyuridine autoantibody titers, a biomarker of oxidized DNA damage, one of the mechanisms by which iron is thought to impact disease risk, was very high (0.97, 95% CI, 0.5-0.99).Our results show that some newly developed iron-related assays could be useful tools to assess iron-disease associations in prospective cohorts that collect a single blood sample.

PubMed ID: 17027294 Exiting the NIEHS site

MeSH Terms: Adult; Analysis of Variance; Autoantibodies/blood; Biomarkers/blood*; Blood Chemical Analysis/methods; Blood Chemical Analysis/standards*; Deoxyuracil Nucleotides/blood; Enzyme-Linked Immunosorbent Assay; Female; Ferritins/analysis; Ferritins/blood*; Humans; Iron/blood*; Middle Aged; New York City; Postmenopause/blood*; Prospective Studies; Reproducibility of Results; Surveys and Questionnaires; Transferrin/analysis

Back
to Top