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Title: Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.

Authors: Skibola, Christine F; Bracci, Paige M; Halperin, Eran; Conde, Lucia; Craig, David W; Agana, Luz; Iyadurai, Kelly; Becker, Nikolaus; Brooks-Wilson, Angela; Curry, John D; Spinelli, John J; Holly, Elizabeth A; Riby, Jacques; Zhang, Luoping; Nieters, Alexandra; Smith, Martyn T; Brown, Kevin M

Published In Nat Genet, (2009 Aug)

Abstract: We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).

PubMed ID: 19620980 Exiting the NIEHS site

MeSH Terms: Chromosomes, Human, Pair 6/genetics*; Genetic Predisposition to Disease*; Genetic Variation*; Humans; Lymphoma, Follicular/genetics*; Lymphoma, Large B-Cell, Diffuse/genetics; Polymorphism, Single Nucleotide/genetics

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