Title: Association between fine particulate matter and oxidative DNA damage may be modified in individuals with hypertension.

Authors: Kim, Jee Young; Prouty, Lacey A; Fang, Shona C; Rodrigues, Ema G; Magari, Shannon R; Modest, Geoffrey A; Christiani, David C

Published In J Occup Environ Med, (2009 Oct)

Abstract: To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals.Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG.Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day.The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.

PubMed ID: 19786898

MeSH Terms: No MeSH terms associated with this publication