Title: Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders.
Authors: Onore, Charity; Enstrom, Amanda; Krakowiak, Paula; Hertz-Picciotto, Irva; Hansen, Robin; Van de Water, Judy; Ashwood, Paul
Published In J Neuroimmunol, (2009 Nov 30)
Abstract: A potential role for T(H)17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular release of IL-17 and IL-23 following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMC) from children with ASD compared to age-matched typically developing controls. Following stimulation, the concentration of IL-23, but not IL-17, was significantly reduced (p=0.021) in ASD compared to controls. Decreased cellular IL-23 production in ASD warrants further research to determine its role on the generation and survival of T(H)17 cells, a cell subset important in neuroinflammatory conditions that may include ASD.
PubMed ID: 19800697
MeSH Terms: Autistic Disorder/immunology*; Autistic Disorder/metabolism*; Autistic Disorder/physiopathology; Biomarkers/metabolism; Cells, Cultured; Child, Preschool; Down-Regulation/drug effects; Down-Regulation/immunology; Encephalitis/complications; Encephalitis/immunology; Encephalitis/physiopathology; Female; Humans; Interleukin-17/metabolism*; Interleukin-23/metabolism*; Leukocytes, Mononuclear/immunology*; Leukocytes, Mononuclear/metabolism*; Male; Neuropsychological Tests; Phytohemagglutinins/immunology; Phytohemagglutinins/pharmacology; Social Behavior; Social Behavior Disorders/diagnosis; Social Behavior Disorders/immunology; Surveys and Questionnaires; T-Lymphocytes, Helper-Inducer/drug effects; T-Lymphocytes, Helper-Inducer/immunology