Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders.

Authors: Onore, Charity; Enstrom, Amanda; Krakowiak, Paula; Hertz-Picciotto, Irva; Hansen, Robin; Van de Water, Judy; Ashwood, Paul

Published In J Neuroimmunol, (2009 Nov 30)

Abstract: A potential role for T(H)17 cells has been suggested in a number of conditions including neurodevelopmental disorders such as autism spectrum disorders (ASD). In the current study, we investigated cellular release of IL-17 and IL-23 following an in-vitro immunological challenge of peripheral blood mononuclear cells (PBMC) from children with ASD compared to age-matched typically developing controls. Following stimulation, the concentration of IL-23, but not IL-17, was significantly reduced (p=0.021) in ASD compared to controls. Decreased cellular IL-23 production in ASD warrants further research to determine its role on the generation and survival of T(H)17 cells, a cell subset important in neuroinflammatory conditions that may include ASD.

PubMed ID: 19800697 Exiting the NIEHS site

MeSH Terms: Autistic Disorder/immunology*; Autistic Disorder/metabolism*; Autistic Disorder/physiopathology; Biomarkers/metabolism; Cells, Cultured; Child, Preschool; Down-Regulation/drug effects; Down-Regulation/immunology; Encephalitis/complications; Encephalitis/immunology; Encephalitis/physiopathology; Female; Humans; Interleukin-17/metabolism*; Interleukin-23/metabolism*; Leukocytes, Mononuclear/immunology*; Leukocytes, Mononuclear/metabolism*; Male; Neuropsychological Tests; Phytohemagglutinins/immunology; Phytohemagglutinins/pharmacology; Social Behavior; Social Behavior Disorders/diagnosis; Social Behavior Disorders/immunology; Surveys and Questionnaires; T-Lymphocytes, Helper-Inducer/drug effects; T-Lymphocytes, Helper-Inducer/immunology

Back
to Top