Title: Iron and menopause: does increased iron affect the health of postmenopausal women?
Authors: Jian, Jinlong; Pelle, Edward; Huang, Xi
Published In Antioxid Redox Signal, (2009 Dec)
Abstract: Estrogen deficiency has been regarded as the main causative factor in menopausal symptoms and diseases. Here, we show that although estrogen decreases by 90%, a concurrent but inverse change occurs in iron levels during menopausal transition. For example, levels of serum ferritin are increased by two- to threefold from before menopause to after menopause. This observation has led us to hypothesize that, in addition to estrogen deficiency, increased iron as a result of menopause could be a risk factor affecting the health of postmenopausal women. Further studies on iron and menopause are clinically relevant and may provide novel therapeutic treatments.
PubMed ID: 19527179
MeSH Terms: Estrogen Replacement Therapy; Female; Humans; Iron/metabolism*; Postmenopause*; Risk Factors