Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Modulation of monooxygenase activities by hematin and 7,8-benzoflavone in fetal tissues of rats, rabbits, and humans.

Authors: Omiecinski, C J; Chao, S T; Juchau, M R

Published In Dev Pharmacol Ther, (1980)

Abstract: The rates of benzo[a]pyrene metabolism were stimulated markedly by micromolar quantities of hematin when assayed with either fetal or maternal extrahepatic tissue parparations (9,000 g supernatant fractions) from rats, rabbits and humans. Enzymatic induction was accompanied by either decreases in the magnitude of hematin stimulation or hematin-mediated inhibition of monooxygenase activities. Additions of 7,8-benzoflavone (BF) resulted in the inhibition of reaction rates in most experiments. With either fetal or maternal hepatic preparations from untreated rabbits, however, BF stimulated enzymatic activities; the greatest simulation occurred in fetal rabbit liver (10-fold). Nevertheless, inducer pretreatment was associated with inhibitory of BF on activities in hepatic homogenates.

PubMed ID: 7438968 Exiting the NIEHS site

MeSH Terms: Adrenal Glands/enzymology; Animals; Benzoflavones/pharmacology*; Cytochrome P-450 Enzyme System/analysis; Enzyme Induction; Female; Fetus/enzymology*; Flavonoids/pharmacology*; Heme/analogs & derivatives*; Hemin/pharmacology*; Humans; Liver/enzymology; Oxygenases/biosynthesis; Oxygenases/metabolism*; Pregnancy; Rabbits; Rats

Back
to Top