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Title: Pesticide induced changes in the mouse hepatic microsomal cytochrome P-450-dependent monooxygenase system and other enzymes.

Authors: Robacker, K M; Kulkarni, A P; Hodgson, E

Published In J Environ Sci Health B, (1981)

Abstract: Livers of mice previously treated with potential inducers were tested for effects on the microsomal cytochrome P-450-dependent monooxygenase system (including its constituent electron transport enzymes) and other enzymes. Microsomes were also examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Pesticides, including chlorinated hydrocarbons, organophosphates, a carbamate, and an insecticide synergistic were tested for induction along with the well known inducers, phenobarbital and 3-methylcholanthrene. The results indicate that the pesticide inducers tested are of the phenobarbital type.

PubMed ID: 7299069 Exiting the NIEHS site

MeSH Terms: Adult; Animals; Cytochrome P-450 Enzyme System/metabolism*; Glutathione/metabolism; Humans; Liver/drug effects; Male; Mice; Mice, Inbred ICR; Microsomes, Liver/enzymology*; Mixed Function Oxygenases/metabolism*; NADH Dehydrogenase/metabolism; Organ Size/drug effects; Oxidoreductases/metabolism*; Pesticides/pharmacology*

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