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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Comparative in vivo genotoxicity and acute hepatotoxicity of three 1,2-dihaloethanes.

Authors: Storer, R D; Conolly, R B

Published In Carcinogenesis, (1983 Nov)

Abstract: Hepatic DNA damage was demonstrated by alkaline DNA unwinding/hydroxylapatite batch chromatography in male B6C3F1 mice treated with non-necrogenic doses of 1,2-dichloroethane, 1-bromo-2-chloroethane, and 1,2-dibromoethane. Intraperitoneal administration of 0.5 mmol/kg of 1-bromo-2-chloroethane and 1,2-dibromoethane produced similar levels of DNA damage. A 4-fold higher dose of 1,2-dichloroethane (2.0 mmol/kg) was required to produce a comparable effect.

PubMed ID: 6357525 Exiting the NIEHS site

MeSH Terms: Animals; DNA/genetics*; Ethane/analogs & derivatives*; Ethane/toxicity; Ethylene Dibromide/toxicity*; Ethylene Dichlorides/toxicity*; Hydrocarbons, Brominated/toxicity*; Hydrocarbons, Chlorinated/toxicity*; Hydrocarbons, Halogenated/toxicity*; Kidney/drug effects; Kidney/pathology; Liver/drug effects*; Liver/pathology; Male; Mice; Mice, Inbred Strains; Mutagens*; Organ Size/drug effects; Structure-Activity Relationship

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