Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium.

Authors: Wolpin, Brian M; Kraft, Peter; Gross, Myron; Helzlsouer, Kathy; Bueno-de-Mesquita, H Bas; Steplowski, Emily; Stolzenberg-Solomon, Rachael Z; Arslan, Alan A; Jacobs, Eric J; Lacroix, Andrea; Petersen, Gloria; Zheng, Wei; Albanes, Demetrius; Allen, Naomi E; Amundadottir, Laufey; Anderson, Garnet; Boutron-Ruault, Marie-Christine; Buring, Julie E; Canzian, Federico; Chanock, Stephen J; Clipp, Sandra; Gaziano, John Michael; Giovannucci, Edward L; Hallmans, Göran; Hankinson, Susan E; Hoover, Robert N; Hunter, David J; Hutchinson, Amy; Jacobs, Kevin; Kooperberg, Charles; Lynch, Shannon M; Mendelsohn, Julie B; Michaud, Dominique S; Overvad, Kim; Patel, Alpa V; Rajkovic, Aleksandar; Sanchéz, Maria-José; Shu, Xiao-Ou; Slimani, Nadia; Thomas, Gilles; Tobias, Geoffrey S; Trichopoulos, Dimitrios; Vineis, Paolo; Virtamo, Jarmo; Wactawski-Wende, Jean; Yu, Kai; Zeleniuch-Jacquotte, Anne; Hartge, Patricia; Fuchs, Charles S

Published In Cancer Res, (2010 Feb 01)

Abstract: A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.

PubMed ID: 20103627 Exiting the NIEHS site

MeSH Terms: ABO Blood-Group System/genetics*; Aged; Alleles*; Cohort Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Pancreatic Neoplasms/genetics*; Risk Factors

Back
to Top