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National Institute of Environmental Health Sciences

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Publication Detail

Title: Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells.

Authors: LaPensee, Elizabeth W; LaPensee, Christopher R; Fox, Sejal; Schwemberger, Sandy; Afton, Scott; Ben-Jonathan, Nira

Published In Cancer Lett, (2010 Apr 28)

Abstract: Resistance to chemotherapy is a major problem facing breast cancer patients. Cisplatin, a highly effective DNA-damaging drug, has shown only little success in breast cancer treatment. We are reporting that low nanomolar doses of bisphenol A (BPA) or estradiol antagonize cisplatin cytotoxicity in breast cancer cells, with their effects not mediated via classical estrogen receptors. Although both compounds increase the expression of Bcl-2, a Bcl-2 inhibitor completely blocked the protective effects of BPA while only partially affecting those of estradiol. Blockade of BPA and E2 actions should sensitize ER-negative breast tumors to anti-cancer drugs and allow for the inclusion of cisplatin in treatment regimens.

PubMed ID: 19796866 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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