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Title: Janus kinase-3 dependent inflammatory responses in allergic asthma.

Authors: Malaviya, Rama; Laskin, Debra L; Malaviya, Ravi

Published In Int Immunopharmacol, (2010 Aug)

Abstract: Allergic asthma is a chronic inflammatory condition of the lung characterized by reversible airway obstruction, high serum immunoglobulin (Ig) E levels, and chronic airway inflammation. A number of cells including mast cells, T cells, macrophages and dendritic cells play a role in the pathogenesis of the disease. Janus kinase (JAK)-3, a non-receptor protein tyrosine kinase, traditionally known to mediate cytokine signaling, also regulates functional responses of these cells. In this review the role of JAK-3 in regulating various pathogenic processes in allergic asthma is discussed. We propose that targeting JAK-3 is a rationale approach to control the inflammatory responses of multiple cell types responsible for the pathogenesis of allergic asthma.

PubMed ID: 20430118 Exiting the NIEHS site

MeSH Terms: Animals; Asthma/drug therapy; Asthma/immunology*; Asthma/metabolism; Dendritic Cells/immunology; Drug Design; Humans; Immunoglobulin E/immunology*; Janus Kinase 3/immunology*; Janus Kinase 3/metabolism; Lung/immunology*; Lung/pathology; Macrophages, Alveolar/immunology; Mast Cells/immunology; Pneumonia; Respiratory Mucosa/immunology; Respiratory Mucosa/metabolism; Signal Transduction/immunology

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