Title: Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
Authors: Arslan, Alan A; Helzlsouer, Kathy J; Kooperberg, Charles; Shu, Xiao-Ou; Steplowski, Emily; Bueno-de-Mesquita, H Bas; Fuchs, Charles S; Gross, Myron D; Jacobs, Eric J; Lacroix, Andrea Z; Petersen, Gloria M; Stolzenberg-Solomon, Rachael Z; Zheng, Wei; Albanes, Demetrius; Amundadottir, Laufey; Bamlet, William R; Barricarte, Aurelio; Bingham, Sheila A; Boeing, Heiner; Boutron-Ruault, Marie-Christine; Buring, Julie E; Chanock, Stephen J; Clipp, Sandra; Gaziano, J Michael; Giovannucci, Edward L; Hankinson, Susan E; Hartge, Patricia; Hoover, Robert N; Hunter, David J; Hutchinson, Amy; Jacobs, Kevin B; Kraft, Peter; Lynch, Shannon M; Manjer, Jonas; Manson, Joann E; McTiernan, Anne; McWilliams, Robert R; Mendelsohn, Julie B; Michaud, Dominique S; Palli, Domenico; Rohan, Thomas E; Slimani, Nadia; Thomas, Gilles; Tjønneland, Anne; Tobias, Geoffrey S; Trichopoulos, Dimitrios; Virtamo, Jarmo; Wolpin, Brian M; Yu, Kai; Zeleniuch-Jacquotte, Anne; Patel, Alpa V; Pancreatic Cancer Cohort Consortium (PanScan)
Published In Arch Intern Med, (2010 May 10)
Abstract: Obesity has been proposed as a risk factor for pancreatic cancer.Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese, > or = 35.0). Models were adjusted for potential confounders.In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI quartile, 1.33; 95% CI, 1.12-1.58; P(trend) < .001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% CI, 1.04-1.69; P(trend) < .03), and in women it was 1.34 (95% CI, 1.05-1.70; P(trend) = .01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% CI, 1.31-2.69; P(trend) = .003) but less so in men.These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.
PubMed ID: 20458087
MeSH Terms: Adult; Aged; Aged, 80 and over; Body Mass Index; Case-Control Studies; Female; Humans; Logistic Models; Male; Middle Aged; Obesity/epidemiology*; Overweight/epidemiology; Pancreatic Neoplasms/epidemiology*; Pancreatic Neoplasms/etiology; Risk Factors; Sex Distribution; United States/epidemiology; Waist Circumference