Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Efficient genome-wide association testing of gene-environment interaction in case-parent trios.

Authors: Gauderman, W James; Thomas, Duncan C; Murcray, Cassandra E; Conti, David; Li, Dalin; Lewinger, Juan Pablo

Published In Am J Epidemiol, (2010 Jul 01)

Abstract: Complex trait variation is likely to be explained by the combined effects of genes, environmental factors, and gene x environment (G x E) interaction. The authors introduce a novel 2-step method for detecting a G x E interaction in a genome-wide association study (GWAS) of case-parent trios. The method utilizes 2 sources of G x E information in a trio sample to construct a screening step and a testing step. Across a wide range of models, this 2-step procedure provides substantially greater power to detect G x E interaction than a standard test of G x E interaction applied genome-wide. For example, for a disease susceptibility locus with minor allele frequency of 15%, a binary exposure variable with 50% prevalence, and a GWAS scan of 1 million markers in 1,000 case-parent trios, the 2-step method provides 87% power to detect a G x E interaction relative risk of 2.3, as compared with only 25% power using a standard G x E test. The method is easily implemented using standard software. This 2-step scan for G x E interaction is independent of any prior scan that may have been conducted for genetic main effects, and thus has the potential to uncover new genes in a GWAS that have not been previously identified.

PubMed ID: 20543031 Exiting the NIEHS site

MeSH Terms: Environment*; Epidemiologic Methods*; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genome, Human; Genome-Wide Association Study/methods*; Humans; Models, Genetic*; Parents*; Polymorphism, Single Nucleotide

to Top