Title: Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.

Authors: Conde, Lucia; Halperin, Eran; Akers, Nicholas K; Brown, Kevin M; Smedby, Karin E; Rothman, Nathaniel; Nieters, Alexandra; Slager, Susan L; Brooks-Wilson, Angela; Agana, Luz; Riby, Jacques; Liu, Jianjun; Adami, Hans-Olov; Darabi, Hatef; Hjalgrim, Henrik; Low, Hui-Qi; Humphreys, Keith; Melbye, Mads; Chang, Ellen T; Glimelius, Bengt; Cozen, Wendy; Davis, Scott; Hartge, Patricia; Morton, Lindsay M; Schenk, Maryjean; Wang, Sophia S; Armstrong, Bruce; Kricker, Anne; Milliken, Sam; Purdue, Mark P; Vajdic, Claire M; Boyle, Peter; Lan, Qing; Zahm, Shelia H; Zhang, Yawei; Zheng, Tongzhang; Becker, Nikolaus; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Butterbach, Katja; Cocco, Pierluigi; Foretova, Lenka; Maynadié, Marc; de Sanjosé, Silvia; Staines, Anthony; Spinelli, John J; Achenbach, Sara J; Call, Timothy G; Camp, Nicola J; Glenn, Martha; Caporaso, Neil E; Cerhan, James R; Cunningham, Julie M; Goldin, Lynn R; Hanson, Curtis A; Kay, Neil E; Lanasa, Mark C; Leis, Jose F; Marti, Gerald E; Rabe, Kari G; Rassenti, Laura Z; Spector, Logan G; Strom, Sara S; Vachon, Celine M; Weinberg, J Brice; Holly, Elizabeth A; Chanock, Stephen; Smith, Martyn T; Bracci, Paige M; Skibola, Christine F

Published In Nat Genet, (2010 Aug)

Abstract: To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma susceptibility. We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)).

PubMed ID: 20639881

MeSH Terms: No MeSH terms associated with this publication