Title: Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor.
Authors: Jacobson, Eric M; Hugo, Eric R; Tuttle, Traci R; Papoian, Ruben; Ben-Jonathan, Nira
Published In Trends Endocrinol Metab, (2010 Nov)
Abstract: Breast and prostate cancers are hormone-sensitive malignancies that afflict millions of women and men. Although prolactin (PRL) is known as a survival factor that supports tumor growth and confers chemoresistance in both cancers, its precise role in these tumors has not been studied extensively. Growth hormone and placental lactogen also bind PRL receptor (PRLR) and mimic some of the actions of PRL. Blockade of the PRLR represents a novel treatment for patients with advanced breast or prostate cancer with limited therapeutic options. This review discusses different approaches for generating PRLR antagonists. Emphasis is placed on technological advances which enable high-throughput screening for small molecule inhibitors of PRLR signaling that could serve as oral medications.
PubMed ID: 20846877
MeSH Terms: Animals; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/therapy*; Carcinoma/therapy*; Female; High-Throughput Screening Assays/methods; Hormone Antagonists/isolation & purification; Hormone Antagonists/therapeutic use; Humans; Male; Models, Biological; Models, Molecular; Molecular Targeted Therapy/methods*; Prostatic Neoplasms/genetics; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/therapy*; Receptors, Prolactin/antagonists & inhibitors*; Receptors, Prolactin/chemistry; Receptors, Prolactin/metabolism; Receptors, Prolactin/physiology; Therapies, Investigational/methods