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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: DNA replication fidelity and cancer.

Authors: Preston, Bradley D; Albertson, Tina M; Herr, Alan J

Published In Semin Cancer Biol, (2010 Oct)

Abstract: Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.

PubMed ID: 20951805 Exiting the NIEHS site

MeSH Terms: Animals; Chromosome Aberrations*; DNA Damage; DNA Mismatch Repair; DNA Repair/genetics*; DNA Replication/genetics*; DNA-Directed DNA Polymerase/genetics; DNA-Directed DNA Polymerase/metabolism; Gene Rearrangement; Humans; Microsatellite Instability; Mutation*; Neoplasms/genetics*; Point Mutation

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