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National Institute of Environmental Health Sciences

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Publication Detail

Title: Synthesis and biological evaluation of retinoid-chalcones as inhibitors of colon cancer cell growth.

Authors: Mizuno, Cassia S; Paul, Shiby; Suh, Nanjoo; Rimando, Agnes M

Published In Bioorg Med Chem Lett, (2010 Dec 15)

Abstract: Based on the observed anticancer activity of chalcones and retinoids, a novel class of retinoid-chalcone hybrids was designed and synthesized. As part of our ongoing studies to discover natural product based anticancer compounds, the retinoid-chalcone hybrids were tested against the colon cancer cell line HT-29. Retinoid like moiety was introduced through Friedel-Crafts alkylation of toluene. Among the synthesized compounds, the cyano derivative (E)-3-(3-oxo-3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-enyl)benzonitrile 8 showed submicromolar inhibitory activity with an IC(50) of 0.66 μM.

PubMed ID: 21041085 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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