Title: Aneuploidy as an early mechanistic event in metal carcinogenesis.
Authors: Wise, Sandra S; Wise, John Pierce
Published In Biochem Soc Trans, (2010 Dec)
Abstract: Aneuploidy has recently been proposed as an initiating event for carcinogenesis. There is significant evidence that carcinogenic metals induce aneuploidy. Here we review the mechanisms for how carcinogenic metals may induce aneuploidy and the evidence that carcinogenic metals induce an aneugenic effect which can destabilize the genome leading to genomic instability and cancer.
PubMed ID: 21118142
MeSH Terms: Aneuploidy*; Animals; Carcinogens/toxicity; Cell Transformation, Neoplastic/chemically induced*; Cell Transformation, Neoplastic/genetics*; Genomic Instability/drug effects; Humans; Metals/toxicity*; Neoplasms/chemically induced*; Neoplasms/genetics*