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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Epigenetic changes in individuals with arsenicosis.

Authors: Smeester, Lisa; Rager, Julia E; Bailey, Kathryn A; Guan, Xiaojun; Smith, Nikia; García-Vargas, Gonzalo; Del Razo, Luz-Maria; Drobná, Zuzana; Kelkar, Hemant; Stýblo, Miroslav; Fry, Rebecca C

Published In Chem Res Toxicol, (2011 Feb 18)

Abstract: Inorganic arsenic (iAs) is an environmental toxicant currently poisoning millions of people worldwide, and chronically exposed individuals are susceptible to arsenicosis or arsenic poisoning. Using a state-of-the-art technique to map the methylomes of our study subjects, we identified a large interactome of hypermethylated genes that are enriched for their involvement in arsenic-associated diseases, such as cancer, heart disease, and diabetes. Notably, we have uncovered an arsenic-induced tumor suppressorome, a complex of 17 tumor suppressors known to be silenced in human cancers. This finding represents a pivotal clue in unraveling a possible epigenetic mode of arsenic-induced disease.

PubMed ID: 21291286 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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