Title: Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases.
Authors: Martinez-Finley, Ebany J; Avila, Daiana Silva; Chakraborty, Sudipta; Aschner, Michael
Published In Metallomics, (2011 Mar)
Abstract: Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.
PubMed ID: 21210060
MeSH Terms: Alzheimer Disease/genetics; Alzheimer Disease/metabolism*; Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/metabolism*; Disease Models, Animal*; Metals/metabolism*; Parkinson Disease/genetics; Parkinson Disease/metabolism*