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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Breast fine-needle aspiration malondialdehyde deoxyguanosine adduct in breast cancer.

Authors: Peluso, Marco; Munnia, Armelle; Risso, Gabriella G; Catarzi, Sandra; Piro, Sara; Ceppi, Marcello; Giese, Roger W; Brancato, Beniamino

Published In Free Radic Res, (2011 Apr)

Abstract: This study has analysed the generation of 3-(2-deoxy-ýý-D-erythro-pentafuranosyl)pyrimido[1,2-ýý]purin-10(3H)-one deoxyguanosine adduct [MýýýdG], a biomarker of oxidative stress and lipid peroxidation, in breast fine-needle aspirate samples of 22 patients with breast cancer, at different clinical stages, in respect to 13 controls. The multivariate analysis show that M(1)dG adduct was higher in cases than in controls (Mean Ratio (MR) = 5.26, 95% CI = 3.16-8.77). Increased MýýýdG was observed in women with a tumour grade 3 and a pathological diameter 2 (MR = 7.61, 95% CI = 3.91-14.80 and MR = 5.75, 95% CI = 3.13-10.59, respectively). A trend with increasing tumour grade and pathological diameter was present (MR = 1.98, 95% CI = 1.57-2.50 and MR = 2.44, 95% CI = 1.71-3.48, respectively). Not significant effects of age and smoking habit were found (MR = 1.58, 95% CI = 0.92-2.72 and MR = 1.68, 95% CI 0.88-3.20, respectively). An increment over the background frequency of MýýýdG can contribute to breast cancer development. Increasing severity of breast tumour can influence DNA damage level.

PubMed ID: 21250785 Exiting the NIEHS site

MeSH Terms: Age Factors; Aged; Animals; Biopsy, Fine-Needle; Breast Neoplasms/epidemiology; Breast Neoplasms/metabolism*; Breast Neoplasms/pathology; Case-Control Studies; Cattle; DNA Adducts/analysis*; DNA Adducts/metabolism; DNA Damage; DNA/analysis; DNA/chemistry; Deoxyguanosine/analysis; Deoxyguanosine/chemistry; Female; Humans; Italy; Lipid Peroxidation; Malondialdehyde/chemistry; Middle Aged; Multivariate Analysis; Oxidative Stress; Purine Nucleosides/analysis*; Purine Nucleosides/chemistry; Purine Nucleosides/metabolism; Risk Factors; Severity of Illness Index; Smoking; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Markers, Biological/analysis*

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