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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: What's so special about RB?

Authors: Burd, Christin E; Sharpless, Norman E

Published In Cancer Cell, (2010 Apr 13)

Abstract: RB, p107, and p130 are highly related proteins, each capable of regulating cellular proliferation. However, only RB is frequently mutated in cancer. In this issue of Cancer Cell, Chicas et al. shed new light on this conundrum, defining a "special," nonredundant role for RB in promoting cellular senescence.

PubMed ID: 20385355 Exiting the NIEHS site

MeSH Terms: Cell Cycle/physiology; Cellular Senescence; Cyclin E/metabolism; DNA Damage; DNA Replication; Humans; Oncogene Proteins/metabolism; Oxidative Stress; Retinoblastoma Binding Proteins/metabolism*

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