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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Quantitative mass spectrometry reveals the epigenome as a target of arsenic.

Authors: Chu, Feixia; Ren, Xuefeng; Chasse, Amanda; Hickman, Taylor; Zhang, Luoping; Yuh, Jessica; Smith, Martyn T; Burlingame, Alma L

Published In Chem Biol Interact, (2011 Jun 30)

Abstract: Recent studies reveal that posttranslational modifications on chromatin proteins, especially histones, organize genomic DNA and mediate various cellular responses to environmental influences. Quantitative mass spectrometric analysis is a powerful approach to reveal these dynamic events on chromatin in a systematic manner. Here, the effects of arsenic exposure on histone epigenetic state were investigated in human UROtsa cells, and a reduction in acetylation level on several histone H3 and H4 lysine residues was detected. Furthermore, MYST1 was shown to be the major histone acetyltransferase for H4 Lys16 and protect UROtsa cells from arsenic toxicity.

PubMed ID: 21075096 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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