Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: High environmental relative moldiness index during infancy as a predictor of asthma at 7 years of age.

Authors: Reponen, Tiina; Vesper, Stephen; Levin, Linda; Johansson, Elisabet; Ryan, Patrick; Burkle, Jeffery; Grinshpun, Sergey A; Zheng, Shu; Bernstein, David I; Lockey, James; Villareal, Manuel; Khurana Hershey, Gurjit K; LeMasters, Grace

Published In Ann Allergy Asthma Immunol, (2011 Aug)

Abstract: Mold exposures may contribute to the development of asthma, but previous studies have lacked a standardized approach to quantifying exposures.To determine whether mold exposures at the ages of 1 and/or 7 years were associated with asthma at the age of 7 years.This study followed up a high-risk birth cohort from infancy to 7 years of age. Mold was assessed by a DNA-based analysis for the 36 molds that make up the Environmental Relative Moldiness Index (ERMI) at the ages of 1 and 7 years. At the age of 7 years, children were evaluated for allergic sensitization and asthma based on symptom history, spirometry, exhaled nitric oxide, and airway reversibility. A questionnaire was administered to the parent regarding the child's asthma symptoms and other potential cofactors.At the age of 7 years, 31 of 176 children (18%) were found to be asthmatic. Children living in a high ERMI value (ýýý5.2) home at 1 year of age had more than twice the risk of developing asthma than those in low ERMI value homes (<5.2) (adjusted odds ratio [aOR], 2.6; 95% confidence interval [CI], 1.10-6.26). Of the other covariates, only parental asthma (aOR, 4.0; 95% CI, 1.69-9.62) and allergic sensitization to house dust mite (aOR, 4.1; 95% CI, 1.55-11.07) were risk factors for asthma development. In contrast, air-conditioning at home reduced the risk of asthma development (aOR, 0.3; 95% CI, 0.14-0.83). A high ERMI value at 7 years of age was not associated with asthma at 7 years of age.Early exposure to molds as measured by ERMI at 1 year of age, but not 7 years of age, significantly increased the risk for asthma at 7 years of age.

PubMed ID: 21802019 Exiting the NIEHS site

MeSH Terms: Age of Onset; Asthma/diagnosis*; Asthma/epidemiology*; Asthma/etiology; Child; Child, Preschool; DNA, Fungal/analysis*; Environmental Exposure/adverse effects; Follow-Up Studies; Fungi/genetics*; Fungi/growth & development; Fungi/immunology; Humans; Infant; Medical History Taking; Prognosis; Questionnaires; Risk; Spirometry

Back
to Top