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Title: Regioselective Iodination of Chlorinated Aromatic Compounds Using Silver Salts.

Authors: Joshi, Sudhir N; Vyas, Sandhya M; Wu, Huimin; Duffel, Michael W; Parkin, Sean; Lehmler, Hans-Joachim

Published In Tetrahedron, (2011 Sep 30)

Abstract: The iodination of chlorinated aromatic compounds using Ag(2)SO(4)/I(2), AgSbF(6)/I(2), AgBF(4)/I(2) and AgPF(6)/I(2) offers access to iodoarenes that are valuable intermediates in organic synthesis. Specifically, iodination of phenols, anisoles and anilines with a 3,5-dichloro substitution pattern preferentially yielded the ortho, para and para iodinated product, respectively. In the case of chlorobenzene and 3-chlorotoluene, AgSbF(6)/I(2), AgBF(4)/I(2) and AgPF(6)/I(2), but not Ag(2)SO(4)/I(2), selectively introduced the iodine in para position to the chlorine substituent.

PubMed ID: 21918585 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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