Title: New strategies in neuroprotection and neurorepair.
Authors: Antonelli, Marta C; Guillemin, Gilles J; Raisman-Vozari, Rita; Del-Bel, Elaine A; Aschner, Michael; Collins, Michael A; Tizabi, Yousef; Moratalla, Rosario; West, Adrian K
Published In Neurotox Res, (2012 Jan)
Abstract: There are currently few clinical strategies in place, which provide effective neuroprotection and repair, despite an intense international effort over the past decades. One possible explanation for this is that a deeper understanding is required of how endogenous mechanisms act to confer neuroprotection. This mini-review reports the proceedings of a recent workshop "Neuroprotection and Neurorepair: New Strategies" (Iguazu Falls, Misiones, Argentina, April 11-13, 2011, Satellite Symposium of the V Neurotoxicity Society Meeting, 2011) in which four areas of active research were identified to have the potential to generate new insights into this field. Topics discussed were (i) metallothionein and other multipotent neuroprotective molecules; (ii) oxidative stress and their signal mediated pathways in neuroregeneration; (iii) neurotoxins in glial cells, and (iv) drugs of abuse with neuroprotective effects.
PubMed ID: 21861211
MeSH Terms: Central Nervous System/drug effects; Metallothionein/analysis; Metallothionein/metabolism*; Nerve Regeneration; Neuroglia/metabolism; Neuroprotective Agents/metabolism*; Neuroprotective Agents/pharmacology; Neurotoxins/toxicity*; Oxidative Stress/physiology*; Substance-Related Disorders/metabolism