Title: Blood lead levels and cumulative blood lead index (CBLI) as predictors of late neurodevelopment in lead poisoned children.
Authors: Nie, Linda H; Wright, Robert O; Bellinger, David C; Hussain, Javed; Amarasiriwardena, Chitra; Chettle, David R; Pejović-Milić, Ana; Woolf, Alan; Shannon, Michael
Published In Biomarkers, (2011 Sep)
Abstract: To find the best lead exposure assessment marker for children.We recruited 11 children, calculated a cumulative blood lead index (CBLI) for the children, measured their concurrent BLL, assessed their development, and measured their bone lead level.Nine of 11 children had clinically significant neurodevelopment problems. CBLI and current blood lead level, but not the peak lead level, were significantly or marginally negatively associated with the full-scale IQ score.Lead exposure at younger age significantly impacts a child's later neurodevelopment. CBLI may be a better predictor of neurodevelopment than are current or peak blood lead levels.
PubMed ID: 21827276
MeSH Terms: Adolescent; Biomarkers/blood*; Bone and Bones/chemistry; Child; Developmental Disabilities/blood*; Developmental Disabilities/chemically induced; Developmental Disabilities/diagnosis; Developmental Disabilities/physiopathology; Female; Humans; Intelligence Tests; Lead Poisoning, Nervous System, Childhood/blood*; Lead Poisoning, Nervous System, Childhood/physiopathology; Lead/adverse effects; Lead/blood*; Male; Nervous System/drug effects; Nervous System/metabolism*; Nervous System/physiopathology; Prospective Studies; United States