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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring.

Authors: Shorey, Lyndsey E; Castro, David J; Baird, William M; Siddens, Lisbeth K; Löhr, Christiane V; Matzke, Melissa M; Waters, Katrina M; Corley, Richard A; Williams, David E

Published In Cancer Lett, (2012 Apr 01)

Abstract: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [(14)C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [(14)C] 3weeks post-dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.

PubMed ID: 22085489 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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