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Publication Detail

Title: Association between prenatal lead exposure and blood pressure in children.

Authors: Zhang, Aimin; Hu, Howard; Sánchez, Brisa N; Ettinger, Adrienne S; Park, Sung Kyun; Cantonwine, David; Schnaas, Lourdes; Wright, Robert O; Lamadrid-Figueroa, Hector; Tellez-Rojo, Martha Maria

Published In Environ Health Perspect, (2012 Mar)

Abstract: Lead exposure in adults is associated with hypertension. Altered prenatal nutrition is associated with subsequent risks of adult hypertension, but little is known about whether prenatal exposure to toxicants, such as lead, may also confer such risks.We investigated the relationship of prenatal lead exposure and blood pressure (BP) in 7- to 15-year-old boys and girls.We evaluated 457 mother-child pairs, originally recruited for an environmental birth cohort study between 1994 and 2003 in Mexico City, at a follow-up visit in 2008-2010. Prenatal lead exposure was assessed by measurement of maternal tibia and patella lead using in vivo K-shell X-ray fluorescence and cord blood lead using atomic absorption spectrometry. BP was measured by mercury sphygmomanometer with appropriate-size cuffs.Adjusting for relevant covariates, maternal tibia lead was significantly associated with increases in systolic BP (SBP) and diastolic BP (DBP) in girls but not in boys (p-interaction with sex = 0.025 and 0.007 for SBP and DBP, respectively). Among girls, an interquartile range increase in tibia lead (13 μg/g) was associated with 2.11-mmHg [95% confidence interval (CI): 0.69, 3.52] and 1.60-mmHg (95% CI: 0.28, 2.91) increases in SBP and DBP, respectively. Neither patella nor cord lead was associated with child BP.Maternal tibia lead, which reflects cumulative environmental lead exposure and a source of exposure to the fetus, is a predisposing factor to higher BP in girls but not boys. Sex-specific adaptive responses to lead toxicity during early-life development may explain these differences.

PubMed ID: 21947582 Exiting the NIEHS site

MeSH Terms: Adolescent; Blood Pressure*; Bone and Bones/chemistry*; Child; Cohort Studies; Environmental Pollutants/toxicity*; Female; Follow-Up Studies; Humans; Hypertension/chemically induced; Hypertension/epidemiology*; Lead/toxicity*; Longitudinal Studies; Male; Mexico/epidemiology; Pregnancy; Prenatal Exposure Delayed Effects/chemically induced; Prenatal Exposure Delayed Effects/epidemiology*; Prospective Studies; Sex Factors; Umbilical Cord/chemistry*

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