Skip Navigation

Publication Detail

Title: Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction.

Authors: Chavarro, Jorge E; Ehrlich, Shelley; Colaci, Daniela S; Wright, Diane L; Toth, Thomas L; Petrozza, John C; Hauser, Russ

Published In Fertil Steril, (2012 Jul)

Abstract: OBJECTIVE: To assess the relation between body mass index (BMI) and short-term weight change with assisted reproductive technology (ART) outcomes. DESIGN: Prospective cohort study. SETTING: Fertility center. PATIENT(S): A total of 170 women undergoing 233 ART cycles. INTERVENTION(S): Baseline BMI and short-term weight change were related to ART outcomes. Regression models accounting for repeated observations were used to adjust data for potential confounders. MAIN OUTCOME MEASURE(S): Peak E2 levels, oocyte yield, MII yield, fertilization rate, embryo quality, postive [beta]-hCH, clinical pregnancy and live birth rates. RESULT(S): Overweight and obesity were associated with lower live birth rates. The adjusted live birth rate (95% confidence interval) was 42% (28%-58%) among women with a BMI between 20 and 22.4 kg/m(2) and 23% (14%-36%) among overweight or obese women. Short-term weight loss was associated with a higher proportion of metaphase II (MII) oocytes retrieved. The adjusted proportion of MII eggs was 91% (87%-94%) for women who lost 3 kg or more and 86% (81%-89%) for women whose weight remained stable. This association was stronger among women who were overweight or obese at baseline. Short-term weight loss was unrelated to positive β-hCG, clinical pregnancy, or live birth rates. CONCLUSION(S): Overweight and obesity were related to lower live birth rates in women undergoing ART. Short-term weight loss was related to higher MII yield, particularly among overweight and obese women, but unrelated to clinical outcomes.

PubMed ID: 22607889 Exiting the NIEHS site

MeSH Terms: Adult; Body Mass Index*; Body Weight/physiology; Cohort Studies; Combined Modality Therapy; Female; Humans; Infertility/complications; Infertility/diagnosis; Infertility/epidemiology; Infertility/therapy*; Male; Obesity/complications; Obesity/diagnosis; Obesity/epidemiology; Obesity/therapy; Oocyte Retrieval/methods; Oocyte Retrieval/standards; Oocyte Retrieval/statistics & numerical data; Overweight/complications; Overweight/diagnosis; Overweight/epidemiology; Overweight/therapy; Pregnancy; Pregnancy Outcome/epidemiology; Reproductive Techniques, Assisted*; Time Factors; Treatment Outcome; Weight Loss/physiology*; Weight Reduction Programs/statistics & numerical data

Back
to Top