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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: DNA methylation screening and analysis.

Authors: Sant, Karilyn E; Nahar, Muna S; Dolinoy, Dana C

Published In Methods Mol Biol, (2012)

Abstract: DNA methylation is an epigenetic form of gene regulation that is universally important throughout the life course, especially during in utero and postnatal development. DNA methylation aids in cell cycle regulation and cellular differentiation processes. Previous studies have demonstrated that DNA methylation profiles may be altered by diet and the environment, and that these profiles are especially vulnerable during development. Thus, it is important to understand the role of DNA methylation in developmental governance and subsequent disease progression. A variety of molecular methods exist to assay for global, gene-specific, and epigenome-wide methylation. Here we describe these methods and discuss their relative strengths and limitations.

PubMed ID: 22669678 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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