Skip Navigation

Publication Detail

Title: 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice.

Authors: Kania-Korwel, Izabela; Barnhart, Christopher D; Stamou, Marianna; Truong, Kim M; El-Komy, Mohammed H M E; Lein, Pamela J; Veng-Pedersen, Peter; Lehmler, Hans-Joachim

Published In Environ Sci Technol, (2012 Oct 16)

Abstract: Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral and undergo enantiomeric enrichment in mammalian species, which may modulate PCB developmental neurotoxicity. This study measures levels and enantiomeric enrichment of PCB 95 and its hydroxylated metabolites (OH-PCBs) in adult female C57Bl/6 mice following subchronic exposure to racemic PCB 95. Tissue levels of PCB 95 and OH-PCBs increased with increasing dose. Dose-dependent enantiomeric enrichment of PCB 95 was observed in brain and other tissues. OH-PCBs also displayed enantiomeric enrichment in blood and liver, but were not detected in adipose and brain. In light of data suggesting enantioselective effects of chiral PCBs on molecular targets linked to PCB developmental neurotoxicity, our observations highlight the importance of accounting for PCB and OH-PCB enantiomeric enrichment in the assessment of PCB developmental neurotoxicity.

PubMed ID: 22974126 Exiting the NIEHS site

MeSH Terms: Animals; Environmental Pollutants/metabolism*; Environmental Pollutants/toxicity; Female; Hydroxylation; Mice; Mice, Inbred C57BL; Polychlorinated Biphenyls/metabolism*; Polychlorinated Biphenyls/toxicity; Stereoisomerism

Back
to Top