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National Institute of Environmental Health Sciences

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Publication Detail

Title: Interplay between vitamin D and the drug metabolizing enzyme CYP3A4.

Authors: Wang, Zhican; Schuetz, Erin G; Xu, Yang; Thummel, Kenneth E

Published In J Steroid Biochem Mol Biol, (2013 Jul)

Abstract: Cytochrome P450 3A4 (CYP3A4) is a multifunctional enzyme involved in both xenobiotic and endobiotic metabolism. This review focuses on two aspects: regulation of CYP3A4 expression by vitamin D and metabolism of vitamin D by CYP3A4. Enterohepatic circulation of vitamin D metabolites and their conjugates will be also discussed. The interplay between vitamin D and CYP3A4 provides new insights into our understanding of how enzyme induction can contribute to vitamin D deficiency. This article is part of a Special Issue entitled 'Vitamin D Workshop'.

PubMed ID: 22985909 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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