Title: Manganese alters rat brain amino acids levels.

Authors: Santos, Dinamene; Batoreu, M Camila; Almeida, Isabel; Ramos, Ruben; Sidoryk-Wegrzynowicz, M; Aschner, Michael; Marreilha dos Santos, A P

Published In Biol Trace Elem Res, (2012 Dec)

Abstract: Manganese (Mn) is an essential element and it acts as a cofactor for a number of enzymatic reactions, including those involved in amino acid, lipid, protein, and carbohydrate metabolism. Excessive exposure to Mn can lead to poisoning, characterized by psychiatric disturbances and an extrapyramidal disorder. Mn-induced neuronal degeneration is associated with alterations in amino acids metabolism. In the present study, we analyzed whole rat brain amino acid content subsequent to four or eight intraperitoneal injections, with 25 mg MnClýýý/kg/day, at 48-h intervals. We noted a significant increase in glycine brain levels after four or eight Mn injections (pýýý<ýýý0.05 and pýýý<ýýý0.01, respectively) and arginine also after four or eight injections (pýýý<ýýý0.001). Significant increases were also noted in brain proline (pýýý<ýýý0.01), cysteine (pýýý<ýýý0.05), phenylalanine (pýýý<ýýý0.01), and tyrosine (pýýý<ýýý0.01) levels after eight Mn injections vs. the control group. These findings suggest that Mn-induced alterations in amino acid levels secondary to Mn affect the neurochemical milieu.

PubMed ID: 22971893

MeSH Terms: No MeSH terms associated with this publication