Skip Navigation

Publication Detail

Title: Plasma fluorescent oxidation products and short-term occupational particulate exposures.

Authors: Hart, Jaime E; Wu, Tianying; Laden, Francine; Garshick, Eric

Published In Am J Ind Med, (2012 Oct)

Abstract: Evidence suggests that fine particulate air pollution results in oxidative induced tissue damage.A global fluorescent oxidation products (FLOx) assay (fluorescent intensity (FI) units per milliliter of plasma) was measured in blood samples collected from 236 nonsmoking, Caucasian, male trucking industry workers either prior to, during, or after their work shifts. Occupational exposures to particulate matter (PM)(2.5) were based on job-specific area-level sampling. Generalized linear models were used to determine associations between FLOx levels and PM(2.5) , adjusted for age, time since last meal, alcohol consumption, aspirin, and cholesterol medications.The mean (standard deviation) level of FLOx was 265.9 FI/ml (96.0). Levels of FLOx were higher among older individuals and lower among those who had consumed alcohol in the past 24 hr. However, no associations were observed between FLOx and PM(2.5) .Our results indicate no association between occupational PM(2.5) exposure and this marker of global oxidative stress.

PubMed ID: 22618714 Exiting the NIEHS site

MeSH Terms: Air Pollutants, Occupational/adverse effects*; Biomarkers; Humans; Linear Models; Male; Middle Aged; Motor Vehicles; Occupational Exposure/adverse effects*; Oxidative Stress*; Particulate Matter/adverse effects*; Risk Factors; Vehicle Emissions/toxicity*

Back
to Top