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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Biomarkers intersect with the exposome.

Authors: Rappaport, Stephen M

Published In Biomarkers, (2012 Sep)

Abstract: The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.

PubMed ID: 22672124 Exiting the NIEHS site

MeSH Terms: Biomarkers/blood; Blood Proteins/metabolism*; Cardiovascular Diseases/blood; Environmental Exposure; Humans; Metabolome*; Metabolomics; Neoplasms/blood; Neurodegenerative Diseases/blood; Proteome/metabolism*; Proteomics

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