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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Association of matrix metalloproteinase-1 polymorphisms with risk of COPD and lung cancer and survival in lung cancer.

Authors: Enewold, Lindsey; Mechanic, Leah E; Bowman, Elise D; Platz, Elizabeth A; Alberg, Anthony J

Published In Anticancer Res, (2012 Sep)

Abstract: The primary risk factor for chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) is cigarette smoking but shared susceptibility factors, such as variations in the matrix metalloproteinase-1 (MMP1) gene, may also underlie both diseases.Cases with prevalent COPD (n=167), incident NSCLC (n=242), or prevalent COPD plus incident NSCLC (n=128) were compared to disease-free controls (n=338) to assess six MMP1 polymorphisms. The association between these polymorphisms and survival in NSCLC was also evaluated.Rs11292517 among African-Americans [odds ratio (OR)=5.48, 95% confidence interval (CI)=1.17-25.72] and rs2071230 among Caucasians (OR=2.51, 95% CI=1.09-5.77) appeared to be associated with NSCLC risk in the presence of COPD. Rs470558 appeared to be associated with survival in NSCLC among African-Americans (hazard ratio=3.94; 95%CI=1.14-13.63). No associations remained after adjusting for multiple comparisons.Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC.

PubMed ID: 22993337 Exiting the NIEHS site

MeSH Terms: African Americans/genetics; Aged; Carcinoma, Non-Small-Cell Lung/enzymology; Carcinoma, Non-Small-Cell Lung/ethnology; Carcinoma, Non-Small-Cell Lung/genetics*; Case-Control Studies; Cohort Studies; European Continental Ancestry Group/genetics; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms/enzymology; Lung Neoplasms/ethnology; Lung Neoplasms/genetics*; Male; Matrix Metalloproteinase 1/genetics*; Middle Aged; Polymorphism, Genetic; Pulmonary Disease, Chronic Obstructive/enzymology; Pulmonary Disease, Chronic Obstructive/ethnology; Pulmonary Disease, Chronic Obstructive/genetics*

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