Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure.

Authors: Manning, Casey M; Johnston, Carl J; Reed, Christina K; Lawrence, B Paige; Williams, Jacqueline P; Finkelstein, Jacob N

Published In Int J Radiat Oncol Biol Phys, (2013 May 01)

Abstract: To address whether irradiation-induced changes in the lung environment alter responses to a viral challenge delivered late after exposure but before the appearance of late lung radiation injury.C57BL/6J mice received either lung alone or combined lung and whole-body irradiation (0-15 Gy). At 10 weeks after irradiation, animals were infected with 120 HAU influenza virus strain A/HKx31. Innate and adaptive immune cell recruitment was determined using flow cytometry. Cytokine and chemokine production and protein leakage into the lung after infection were assessed.Prior irradiation led to a dose-dependent failure to regain body weight after infection and exacerbated mortality, but it did not affect virus-specific immune responses or virus clearance. Surviving irradiated animals displayed a persistent increase in total protein in bronchoalveolar lavage fluid and edema.Lung irradiation increased susceptibility to death after infection with influenza virus and impaired the ability to complete recovery. This altered response does not seem to be due to a radiation effect on the immune response, but it may possibly be an effect on epithelial repair.

PubMed ID: 23195776 Exiting the NIEHS site

MeSH Terms: Adaptive Immunity/immunology; Animals; Bronchoalveolar Lavage Fluid/chemistry; Chemokines/immunology; Cytokines/immunology; Disease Models, Animal; Dose-Response Relationship, Radiation; Female; Hematopoietic Stem Cells/radiation effects; Immunity, Innate/immunology; Immunoglobulin G/analysis; Immunoglobulin G/immunology; Influenza A virus*/immunology; Lung/immunology; Lung/radiation effects*; Lung/virology; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections/immunology; Orthomyxoviridae Infections/mortality*; Orthomyxoviridae Infections/virology; Proteins/analysis; Weight Loss; Whole-Body Irradiation/adverse effects

Back
to Top