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Publication Detail

Title: Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition.

Authors: Curran, Colleen S; Keely, Patricia J

Published In Matrix Biol, (2013 Mar 11)

Abstract: The components that comprise the extracellular matrix (ECM) are integral to normal tissue homeostasis as well as the development and progression of breast tumors. The secretion, construction, and remodeling of the ECM are each regulated by a complex interplay between tumor cells, fibroblasts and macrophages. Transforming growth factor-β (TGF-β) is an essential molecule in regulating the cellular production of ECM molecules and the adhesive interactions of cells with the ECM. Additionally, hypoxic cell signals, initiated by oxygen deprivation, additional metabolic factors or receptor activation, are associated with ECM formation and the progression of breast cancer. Both TGF-β and hypoxic cell signals are implicated in the functional and morphological changes of cancer-associated-fibroblasts and tumor-associated-macrophages. Moreover, the enhanced recruitment of tumor and stromal cells in response to hypoxia-induced chemokines leads to increased ECM deposition and remodeling, increased blood vessel formation, and enhanced tumor migration. Thus, elucidation of the collaborative networks between tumor and stromal cells in response to the combined signals of TGF-β and hypoxia may yield insight into treatment parameters that target both tumor and stromal cells.

PubMed ID: 23262216 Exiting the NIEHS site

MeSH Terms: Breast Neoplasms/genetics*; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Communication; Extracellular Matrix/metabolism*; Extracellular Matrix/pathology; Female; Fibroblasts/metabolism; Fibroblasts/pathology; Humans; Hypoxia; Phosphorylation; Signal Transduction; Stromal Cells/cytology; Stromal Cells/metabolism*; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism*

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