Title: Particulate matter containing environmentally persistent free radicals and adverse infant respiratory health effects: a review.
Authors: Saravia, Jordy; Lee, Greg I; Lomnicki, Slawo; Dellinger, Barry; Cormier, Stephania A
Published In J Biochem Mol Toxicol, (2013 Jan)
Abstract: The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are also at significant risk for exposure. Infants are affected differently than adults due to drastic immaturities, both physiologically and immunologically, and it is becoming apparent that they represent a critically understudied population. Highlighting our work funded by the ONES award, in this review we argue the understated importance of utilizing infant models to truly understand the etiology of PM-induced predisposition to severe, persistent lung disease. We also touch upon various mechanisms of PM-mediated respiratory damage, with a focus on the emerging importance of environmentally persistent free radicals (EPFRs) ubiquitously present in combustion-derived PM. In conclusion, we briefly comment on strengths/challenges facing current PM research, while giving perspective on how we may address these challenges in the future.
PubMed ID: 23281110
MeSH Terms: Air Pollutants/analysis; Air Pollutants/toxicity*; Asthma/chemically induced; Free Radicals/analysis; Free Radicals/toxicity*; Humans; Infant; Infant Welfare*; Lung Diseases/chemically induced; Lung Diseases/immunology; Lung/drug effects; Lung/immunology; Oxidative Stress; Particulate Matter/toxicity*