Skip Navigation

Publication Detail

Title: Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat.

Authors: Conney, Allan H; Lou, You-Rong; Nghiem, Paul; Bernard, Jamie J; Wagner, George C; Lu, Yao-Ping

Published In Top Curr Chem, (2013)

Abstract: Oral administration of green tea, black tea, or caffeine (but not the decaffeinated teas) inhibited ultraviolet B radiation (UVB)-induced skin carcinogenesis in SKH-1 mice. Studies with caffeine indicated that its inhibitory effect on the ATR/Chk1 pathway is an important mechanism for caffeine's inhibition of UVB-induced carcinogenesis. The regular teas or caffeine increased locomotor activity and decreased tissue fat. In these studies, decreased dermal fat thickness was associated with a decrease in the number of tumors per mouse. Administration of caffeine, voluntary exercise, and removal of the parametrial fat pads all stimulated UVB-induced apoptosis, inhibited UVB-induced carcinogenesis, and stimulated apoptosis in UVB-induced tumors. These results suggest that caffeine administration, voluntary exercise, and removal of the parametrial fat pads inhibit UVB-induced carcinogenesis by stimulating UVB-induced apoptosis and by enhancing apoptosis in DNA-damaged precancer cells and in cancer cells. We hypothesize that tissue fat secretes antiapoptotic adipokines that have a tumor promoting effect.

PubMed ID: 22752580 Exiting the NIEHS site

MeSH Terms: Adipose Tissue/drug effects*; Administration, Oral; Animals; Apoptosis/radiation effects; Caffeine/administration & dosage; Caffeine/pharmacology*; Mice; Neoplasms, Radiation-Induced/pathology; Neoplasms, Radiation-Induced/prevention & control*; Physical Conditioning, Animal*; Skin Neoplasms/etiology; Skin Neoplasms/pathology; Skin Neoplasms/prevention & control*; Tea*; Ultraviolet Rays*

Back
to Top