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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Cancer prevention by tocopherols and tea polyphenols.

Authors: Yang, Chung S; Li, Guangxun; Yang, Zhihong; Guan, Fei; Chen, Amber; Ju, Jihyeung

Published In Cancer Lett, (2013 Jun 28)

Abstract: Tocopherols (vitamin E) and tea polyphenols have been reported to have cancer preventive activities. Large-scale human trials with high doses of alpha-tocopherol, however, have produced disappointing results. This review presents data showing that - and -tocopherols inhibit colon, lung, mammary and prostate carcinogenesis in animal models, whereas -tocopherol is ineffective in animal and human studies. Possible mechanisms of action are discussed. A broad cancer preventive activity of green tea polyphenols has been demonstrated in animal models, and many mechanisms have been proposed. The cancer preventive activity of green tea in humans, however, has not been conclusively demonstrated and remains to be further investigated.

PubMed ID: 23403075 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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