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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Manganese neurotoxicity and the role of reactive oxygen species.

Authors: Martinez-Finley, Ebany J; Gavin, Claire E; Aschner, Michael; Gunter, Thomas E

Published In Free Radic Biol Med, (2013 Sep)

Abstract: Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.

PubMed ID: 23395780 Exiting the NIEHS site

MeSH Terms: Adenosine Triphosphate/biosynthesis; Antioxidants/metabolism; Free Radicals/metabolism; Humans; Manganese Poisoning*; Manganese/metabolism*; Manganese/pharmacology; Mitochondria/metabolism; Mitochondria/pathology; Neurons/metabolism*; Neurons/pathology; Oxidative Stress*; Reactive Oxygen Species

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