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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Non-replication of an association of Apolipoprotein E2 with sinistrality.

Authors: Piper, Brian J; Yasen, Alia L; Taylor, Amy E; Ruiz, Jonatan R; Gaynor, J William; Dayger, Catherine A; Gonzalez-Gross, Marcela; Kwon, Oh D; Nilsson, Lars-Göran; Day, Ian N M; Raber, Jacob; Miller, Jeremy K

Published In Laterality, (2013)

Abstract: A recent report found that left-handed adolescents were more than three times more likely to have an Apolipoprotein (APOE) ϵ2 allele. This study was unable to replicate this association in young adults (N=166). A meta-analysis of nine other datasets (N=360 to 7559, Power > 0.999) including that of National Alzheimer's Coordinating Center also failed to find an over-representation of ϵ2 among left-handers indicating that this earlier outcome was most likely a statistical artefact.

PubMed ID: 22721421 Exiting the NIEHS site

MeSH Terms: Adolescent; Alleles*; Apolipoproteins E/genetics*; Female; Functional Laterality/genetics*; Genetic Association Studies; Genotype; Humans; Male; Young Adult

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