Title: Balancing the risks and benefits of oxygen therapy in critically III adults.
Authors: Budinger, G R Scott; Mutlu, Gökhan M
Published In Chest, (2013 Apr)
Abstract: Oxygen therapy is an integral part of the treatment of critically ill patients. Maintenance of adequate oxygen delivery to vital organs often requires the administration of supplemental oxygen, sometimes at high concentrations. Although oxygen therapy is lifesaving, it may be associated with deleterious effects when administered for prolonged periods at high concentrations. Here, we review the recent advances in our understanding of the molecular responses to hypoxia and high levels of oxygen and review the current guidelines for oxygen therapy in critically ill patients.
PubMed ID: 23546490
MeSH Terms: Critical Illness/therapy*; Dose-Response Relationship, Drug; Humans; Hypoxia/complications; Hypoxia/epidemiology*; Lung Injury/epidemiology; Lung Injury/etiology; Oxygen/adverse effects*; Oxygen/therapeutic use*; Practice Guidelines as Topic; Risk Assessment; Risk Factors