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Title: NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.

Authors: Pranski, Elaine; Van Sanford, Carson D; Dalal, Nirjari; Orr, Adam L; Karmali, Dipan; Cooper, Deborah S; Gearing, Marla; Lah, James J; Levey, Allan I; Betarbet, Ranjita

Published In Neurosci Lett, (2013 Jun 28)

Abstract: RING finger protein 11 (RNF11), a negative regulator of NF-κB signaling pathway, colocalizes with α-synuclein and is sequestered in Lewy bodies in Parkinson's disease (PD). Since persistent NF-κB activation is reported in PD, in this report we investigated if RNF11 expression level is correlated to activated NF-κB in PD. We examined RNF11 expression levels in correlation to phospho-p65, a marker for activated NF-κB, in control and PD brain tissue from cerebral cortex. In addition we performed double immunofluorescence labeling experiments to confirm this correlation. Our investigations demonstrated that the neuronal RNF11 expression was down-regulated in PD and was usually associated with increased expression of phospho-p65. Double labeling confirmed that loss of neuronal RNF11 was linked to increased phospho-p65 expression, suggesting that persistent presence of NF-κB activation could be due to decreased levels of its negative regulator. Our data exemplifies the relevance of RNF11 and persistent NF-κB activation in PD.

PubMed ID: 23669642 Exiting the NIEHS site

MeSH Terms: Brain/metabolism*; Carrier Proteins/analysis; Carrier Proteins/metabolism*; Fluorescent Antibody Technique; Humans; NF-kappa B/analysis; NF-kappa B/metabolism*; Parkinson Disease/metabolism*

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