Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Animal models of the polycystic ovary syndrome phenotype.

Authors: Padmanabhan, Vasantha; Veiga-Lopez, Almudena

Published In Steroids, (2013 Aug)

Abstract: The etiology of the polycystic ovary syndrome (PCOS) remains unclear, despite its high prevalence among infertility disorders in women of reproductive age. Although there is evidence for a genetic component of the disorder, other causes, such as prenatal insults are considered among the potential factors that may contribute to the development of the syndrome. Over the past few decades, several animal models have been developed in an attempt to understand the potential contribution of exposure to excess steroids on the development of this syndrome. The current review summarizes the phenotypes of current animal models exposed to excess steroid during the prenatal and early postnatal period and how they compare with the phenotype seen in women with PCOS.

PubMed ID: 23701728 Exiting the NIEHS site

MeSH Terms: Animals; Disease Models, Animal*; Female; Humans; Phenotype; Polycystic Ovary Syndrome/genetics; Polycystic Ovary Syndrome/physiopathology*; Pregnancy; Prenatal Exposure Delayed Effects/physiopathology*; Steroids/metabolism; Steroids/physiology*

Back
to Top