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Title: Rare-earth-doped biological composites as in vivo shortwave infrared reporters.

Authors: Naczynski, D J; Tan, M C; Zevon, M; Wall, B; Kohl, J; Kulesa, A; Chen, S; Roth, C M; Riman, R E; Moghe, P V

Published In Nat Commun, (2013)

Abstract: The extension of in vivo optical imaging for disease screening and image-guided surgical interventions requires brightly emitting, tissue-specific materials that optically transmit through living tissue and can be imaged with portable systems that display data in real-time. Recent work suggests that a new window across the short-wavelength infrared region can improve in vivo imaging sensitivity over near infrared light. Here we report on the first evidence of multispectral, real-time short-wavelength infrared imaging offering anatomical resolution using brightly emitting rare-earth nanomaterials and demonstrate their applicability toward disease-targeted imaging. Inorganic-protein nanocomposites of rare-earth nanomaterials with human serum albumin facilitated systemic biodistribution of the rare-earth nanomaterials resulting in the increased accumulation and retention in tumour tissue that was visualized by the localized enhancement of infrared signal intensity. Our findings lay the groundwork for a new generation of versatile, biomedical nanomaterials that can advance disease monitoring based on a pioneering infrared imaging technique.

PubMed ID: 23873342 Exiting the NIEHS site

MeSH Terms: Animals; Humans; Infrared Rays; Melanoma/diagnosis*; Metals, Rare Earth/chemistry*; Mice; Mice, Nude; Molecular Probes*/chemical synthesis; Molecular Probes*/pharmacokinetics; Nanocomposites*/chemistry; Neoplasm Transplantation; Optical Imaging/instrumentation; Optical Imaging/methods*; Radio Waves; Serum Albumin/chemistry; Skin Neoplasms/diagnosis*; Spectroscopy, Near-Infrared; Tissue Distribution

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